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PRP (Platelet Rich Plasma)

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PRP (Platelet Rich Plasma)

PRP (Platelet Rich Plasma) was introduced as an idea in the 1970s. Autologous PRP was first used in open heart surgery in 1987. It was started to be used in dental surgery and hemophilic patients in 1998.

The widespread acceptance of PRP use in society is due to the sports injury suffered by the Super Bowl Pittsburgh Steelers player in 2009.

The player is treated with PRP and makes it to the final match. The fate of PRP changes when this event is reported in The New York Times.

What is PRP?

  • PRP (Platelet Rich Plasma) is the abbreviation of the treatment method called Platelet Rich Plasma.
  • PRP, as an enriched source of platelets, is called plasma containing many growth factors and cytokines that promote tissue and bone healing.

BLOOD & PRP CONTENT

  •      Blood content +93% RBCs
  •      6 % Platelets
  •      1% WBCs
  •      Plasma
  •      PRP content
  •      94 % Platelets and Plasma
  •      5% WBCs

How Does PRP Work?

  •      The body's first response to soft tissue damage is to summon platelets.
  •      Platelets loaded with growth and healing factors initiate to attract repair elements and stem cells to the damaged area. In addition, it contributes to the formation of new vessels and increases the blood supply of that area.
  •      Increased blood supply means better nutrition of the damaged area and better disposal of harmful residues.
  •      An interesting feature of PRP is that it is a very balanced growth factor cocktail. Almost all of the required factors are provided with PRP.

PRP Indications

  •     Sports injuries (tendonapathy, tendon tears, cartilage damage, etc.)
  •     osteoarthritis
  •     Anti-Aging applications
  •     Wrinkles and Skin Regeneration
  •     Hair Transplantation and Hair Loss
  •     Burn Treatment
  •     Wound Treatment
  •     dental practices

Are the Results of Every PRP the Same?

PRP Kits are generally divided into two;

Low Concentration Kits: Kits that can obtain 2-3 times more platelet concentration than the platelet amount in whole blood. (Kits that are obtained by a single centrifuge, generally in the appearance of a laboratory tube and containing a special separating gel)

High Concentration Kits: Kits that can obtain 5-9 times more platelet concentration than the platelet amount in whole blood. (Kits using the Double Centrifuge method and generally mechanically separating and enriching)

Common PRP Application Areas

  •     Joint calcification (Osteoarthritis): Knee, shoulder, hip, neck and waist osteoarthritis
  •     Shoulder pains: Rotator manson injuries (with or without thorns) injuries.
  •     Chronic plantar fasciitis (with or without heel spurs)
  •     Anterior cruciate ligament injuries
  •     Tennis and golfer's elbow
  •     ankle sprains
  •     tendinitis
  •     ligament strains
  •     Meniscus tear
  •     muscle rheumatism
  •     Pelvic pain and instability
  •     Neck and lower back pain

Are the Results of Every PRP the Same?

It seems more likely to obtain more growth factors and better clinical results with higher Platelet concentration.

The second parameter is whether the obtained PRP contains white blood cells. PRP applications that include white blood cells have a different biological activity than PRP applications that do not.

Low-concentration PRP Kits separate whole blood into two different components. Plasma containing red blood cells and platelets.

High-concentration PRP Kits, on the other hand, separate whole blood into three different components. Red blood cells, plasma containing platelets and BUFFY COAT. Buffy Coat Contains Platelets and White Blood Cells

Buffy Coat

Buffy Coat; It is a rich source of cells and proteins that optimize the healing process. These;

  •     Growth Factors
  •     platelets
  •     White Blood Cells
  •     Cytokines and Adhesion Molecules
  •     CD34+ Cells
  •     PRP Kits used in PRP treatment; The amount of platelets they separate differ according to the presence of Buffy Coat and white blood cells in the obtained PRP plasma.

    Therefore, the clinical results of each PRP Kit differ.

"The clinical results of each PRP Kit are not the same."

    Studies have shown that adequate platelet count cannot be achieved with laboratory tubes.

In order to achieve optimal clinical results in PRP treatment, PRP Kits with high platelet concentration should be used.

What Should Meat Be Like A PRP Therapy?

Many different parameters need to be considered in order to define an effective PRP Therapy;

  •     How many times the PRP Kit used in the application increases the platelet concentration compared to the platelet count in whole blood.
  •     Whether it contains white blood cells.
  •     Whether anticoagulants are used.
  •     Whether platelets are activated from the outside.

It has been shown in clinical studies that a PRP Therapy must meet certain conditions in order to be effective. These conditions are;

  •     Containing scaffold (Collagen Skeleton) for cell migration,
  •     Contain progenitor cells that can transform into bone or soft tissue,
  •     It contains signaling proteins that will modulate the repair and remodeling process. These mentioned key cells are located in the “Buffy Coat” layer.

What is the Effective Dose in PRP Therapy?

Under normal conditions, the approximate amount of platelets in human blood is around 150,000-350,000 per microliter.

In clinical studies, it has been emphasized that the value of platelets in whole blood should be increased at least 4-5 times in order to provide an effective treatment in PRP treatment.

If we accept the value of the average platelet in whole blood in humans as 200,000 per microliter, the amount of platelets in the PRP solution should be 800,000-1,000,000 per microliter.

To get the optimal effect in clinical results, this should be the therapeutic dose amount in cin PRP.

As a result;

PRP (Platelet Rich Plasma) platelet (thrombocyte) enriched plasma application is the abbreviated name of the treatment method given. It is a newly developed treatment option in modern medicine called "orthobiologics". The aim of this treatment is to stimulate the body's ability to repair and renew itself. Orthobiology is a newly developing science and it is aimed to stimulate bone and tissue healing with the application of materials obtained through biological means. The blood taken from the patients is to be able to separate the red blood cells from the white cells and plasma with the help of a gel in a special tube after the centrifugation process is applied. Once this plasma is obtained, it is given to the patient's scalp or various parts of the skin in different ways. Platelets, also known as platelets, are blood components that contain the growth factors necessary to repair damaged tissues in our body and return them to their natural state. When any damage occurs in our tissues, our blood starts a repair process by collecting platelets in this tissue. The purpose of PRP application is to give a much larger number of platelets that can be transported to this target tissue by blood circulation. The density of platelets obtained with PRP is 2 to 4 times higher than that in blood.

Thus, aged and damaged skin and subdermal tissues are stimulated and renewed, thus biological stimulation begins to produce a new dermis. It is a safe practice to process the patient's own blood and give it back to the patient. These processes are carried out with the help of a sterile and closed kit, so there is no risk of contamination for any microorganism from the outside.

The release of growth factors from activated platelets begins within the first 10 minutes and is completed within an hour. Therefore, the prepared PRP concentration should be applied to the required area within 10 minutes16. The application technique is the same as the mesotherapy technique. Injections are made as superficial intradermal injections.